Publications

Taiber, S., Gwilliam, K., Hertzano, R., & Avraham, K. B. (2022). The Genomics of Auditory Function and Disease. Annual review of genomics and human genetics, 10.1146/annurev-genom-121321-094136. Advance online publication. https://doi.org/10.1146/annurev-genom-121321-094136

Trpchevska, N., Freidin, M. B., Broer, L., Oosterloo, B. C., Yao, S., Zhou, Y., Vona, B., Bishop, C., Bizaki-Vallaskangas, A., Canlon, B., Castellana, F., Chasman, D. I., Cherny, S., Christensen, K., Concas, M. P., Correa, A., Elkon, R., Estonian Biobank Research Team, Mengel-From, J., Gao, Y., … Nagtegaal, A. P. (2022). Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss. American journal of human genetics, 109(6), 1077–1091. https://doi.org/10.1016/j.ajhg.2022.04.010

Hertzano, R., Mahurkar, A. (2022) Advancing discovery in hearing research via biologist-friendly access to multi-omic data. Human Genetics. https://doi.org/10.1007/s00439-022-02445-w

Shuster, B., Casserly, R., Lipford, E., Olszewski, R., Milon, B., Viechweg, S., … Hertzano, R. (2021). Estradiol Protects against Noise-Induced Hearing Loss and Modulates Auditory Physiology in Female Mice. International Journal of Molecular Sciences, 22(22), 12208. https://doi.org/10.3390/ijms222212208

Udagawa, T., Atkinson, P. J., Milon, B., Abitbol, J. M., Song, Y., Sperber, M., Huarcaya Najarro, E., Scheibinger, M., Elkon, R., Hertzano, R., & Cheng, A. G. (2021). Lineage-tracing and translatomic analysis of damage-inducible mitotic cochlear progenitors identifies candidate genes regulating regeneration. PLoS biology, 19(11), e3001445. Advance online publication. https://doi.org/10.1371/journal.pbio.3001445

BRAIN Initiative Cell Census Network (BICCN) (2021). A multimodal cell census and atlas of the mammalian primary motor cortex. Nature, 598(7879), 86–102. https://doi.org/10.1038/s41586-021-03950-0

Yao, Z., Liu, H., Xie, F., Fischer, S., Adkins, R. S., Aldridge, A. I., Ament, S. A., Bartlett, A., Behrens, M. M., Van den Berge, K., Bertagnolli, D., de Bézieux, H. R., Biancalani, T., Booeshaghi, A. S., Bravo, H. C., Casper, T., Colantuoni, C., Crabtree, J., Creasy, H., Crichton, K., … Mukamel, E. A. (2021). A transcriptomic and epigenomic cell atlas of the mouse primary motor cortex. Nature, 598(7879), 103–110. https://doi.org/10.1038/s41586-021-03500-8

Bakken, T. E., Jorstad, N. L., Hu, Q., Lake, B. B., Tian, W., Kalmbach, B. E., Crow, M., Hodge, R. D., Krienen, F. M., Sorensen, S. A., Eggermont, J., Yao, Z., Aevermann, B. D., Aldridge, A. I., Bartlett, A., Bertagnolli, D., Casper, T., Castanon, R. G., Crichton, K., Daigle, T. L., … Lein, E. S. (2021). Comparative cellular analysis of motor cortex in human, marmoset and mouse. Nature, 598(7879), 111–119. https://doi.org/10.1038/s41586-021-03465-8

Milon, B., Shulman, E. D., So, K. S., Cederroth, C. R., Lipford, E. L., Sperber, M., Sellon, J. B., Sarlus, H., Pregernig, G., Shuster, B., Song, Y., Mitra, S., Orvis, J., Margulies, Z., Ogawa, Y., Shults, C., Depireux, D. A., Palermo, A. T., Canlon, B., Burns, J., … Hertzano, R. (2021). A cell-type-specific atlas of the inner ear transcriptional response to acoustic trauma. Cell reports, 36(13), 109758. https://doi.org/10.1016/j.celrep.2021.109758

Orvis, J., Gottfried, B., Kancherla, J., Adkins, R. S., Song, Y., Dror, A. A., Olley, D., Rose, K., Chrysostomou, E., Kelly, M. C., Milon, B., Matern, M. S., Azaiez, H., Herb, B., Colantuoni, C., Carter, R. L., Ament, S. A., Kelley, M. W., White, O., Bravo, H. C., … Hertzano, R. (2021). gEAR: Gene Expression Analysis Resource portal for community-driven, multi-omic data exploration. Nature methods, 18(8), 843–844. https://doi.org/10.1038/s41592-021-01200-9

Lee, L., Shuster, B., Song, Y., Kujawa, S. G., Depireux, D., & Hertzano, R. (2021). Music level preference and perceived exercise intensity in group spin classes. Noise & health, 23(108), 42–49. https://doi.org/10.4103/nah.NAH_65_20

Hertzano, R., Gwilliam, K., Rose, K., Milon, B., & Matern, M. S. (2021). Cell Type-Specific Expression Analysis of the Inner Ear: A Technical Report. The Laryngoscope, 131 Suppl 5, S1–S16. https://doi.org/10.1002/lary.28765

Engeln, M., Song, Y., Chandra, R., La, A., Fox, M. E., Evans, B., Turner, M. D., Thomas, S., Francis, T. C., Hertzano, R., & Lobo, M. K. (2021). Individual differences in stereotypy and neuron subtype translatome with TrkB deletion. Molecular psychiatry, 26(6), 1846–1859. https://doi.org/10.1038/s41380-020-0746-0

Brownstein, Z., Gulsuner, S., Walsh, T., Martins, F., Taiber, S., Isakov, O., Lee, M. K., Bordeynik-Cohen, M., Birkan, M., Chang, W., Casadei, S., Danial-Farran, N., Abu-Rayyan, A., Carlson, R., Kamal, L., Arnthórsson, A. Ö., Sokolov, M., Gilony, D., Lipschitz, N., Frydman, M., … Avraham, K. B. (2020). Spectrum of genes for inherited hearing loss in the Israeli Jewish population, including the novel human deafness gene ATOH1. Clinical genetics, 98(4), 353–364. https://doi.org/10.1111/cge.13817

Kalra, G., Milon, B., Casella, A. M., Herb, B. R., Humphries, E., Song, Y., Rose, K. P., Hertzano, R., & Ament, S. A. (2020). Biological insights from multi-omic analysis of 31 genomic risk loci for adult hearing difficulty. PLoS genetics, 16(9), e1009025. https://doi.org/10.1371/journal.pgen.1009025

Matern, M. S., Milon, B., Lipford, E. L., McMurray, M., Ogawa, Y., Tkaczuk, A., Song, Y., Elkon, R., & Hertzano, R. (2020). GFI1 functions to repress neuronal gene expression in the developing inner ear hair cells. Development, 147(17), dev186015. https://doi.org/10.1242/dev.186015

Bauer, C. A., Depireux, D., & Hertzano, R. (2020). Tinnitus: Clinical, Basic Science, Audiologic and Industry Updates. Otolaryngologic clinics of North America, 53(4), xvii–xviii. https://doi.org/10.1016/j.otc.2020.04.003

Sadler, E., Ryals, M. M., May, L. A., Martin, D., Welsh, N., Boger, E. T., Morell, R. J., Hertzano, R., & Cunningham, L. L. (2020). Cell-Specific Transcriptional Responses to Heat Shock in the Mouse Utricle Epithelium. Frontiers in cellular neuroscience, 14, 123. https://doi.org/10.3389/fncel.2020.00123

Kolla, L., Kelly, M. C., Mann, Z. F., Anaya-Rocha, A., Ellis, K., Lemons, A., Palermo, A. T., So, K. S., Mays, J. C., Orvis, J., Burns, J. C., Hertzano, R., Driver, E. C., & Kelley, M. W. (2020). Characterization of the development of the mouse cochlear epithelium at the single cell level. Nature communications, 11(1), 2389. https://doi.org/10.1038/s41467-020-16113-y

Shader, M. J., Nguyen, N., Cleary, M., Hertzano, R., Eisenman, D. J., Anderson, S., Gordon-Salant, S., & Goupell, M. J. (2020). Effect of Stimulation Rate on Speech Understanding in Older Cochlear-Implant Users. Ear and hearing, 41(3), 640–651. https://doi.org/10.1097/AUD.0000000000000793

Hertzano, R., Lipford, E. L., & Depireux, D. (2020). Noise: Acoustic Trauma to the Inner Ear. Otolaryngologic clinics of North America, S0030-6665(20)30045-1. Advance online publication. https://doi.org/10.1016/j.otc.2020.03.008

Brooks, P. M., Rose, K. P., MacRae, M. L., Rangoussis, K. M., Gurjar, M., Hertzano, R., & Coate, T. M. (2020). Pou3f4-expressing otic mesenchyme cells promote spiral ganglion neuron survival in the postnatal mouse cochlea. The Journal of comparative neurology, 10.1002/cne.24867. Advance online publication. https://doi.org/10.1002/cne.24867

Clifford, R. E., Hertzano, R., & Ohlemiller, K. K. (2019). Untangling the genomics of noise-induced hearing loss and tinnitus: Contributions of Mus musculus and Homo sapiens. The Journal of the Acoustical Society of America, 146(5), 4007. https://doi.org/10.1121/1.5132552

Dunbar, L. A., Patni, P., Aguilar, C., Mburu, P., Corns, L., Wells, H. R., Delmaghani, S., Parker, A., Johnson, S., Williams, D., Esapa, C. T., Simon, M. M., Chessum, L., Newton, S., Dorning, J., Jeyarajan, P., Morse, S., Lelli, A., Codner, G. F., Peineau, T., … Bowl, M. R. (2019). Clarin-2 is essential for hearing by maintaining stereocilia integrity and function. EMBO molecular medicine, 11(9), e10288. https://doi.org/10.15252/emmm.201910288

Shuster, B. Z., Depireux, D. A., Mong, J. A., & Hertzano, R. (2019). Sex differences in hearing: Probing the role of estrogen signaling. The Journal of the Acoustical Society of America, 145(6), 3656. https://doi.org/10.1121/1.5111870

Nesmith, J. E., Hostelley, T. L., Leitch, C. C., Matern, M. S., Sethna, S., McFarland, R., Lodh, S., Westlake, C. J., Hertzano, R., Ahmed, Z. M., & Zaghloul, N. A. (2019). Genomic knockout of alms1 in zebrafish recapitulates Alström syndrome and provides insight into metabolic phenotypes. Human molecular genetics, 28(13), 2212–2223. https://doi.org/10.1093/hmg/ddz053

Jung, J. S., Zhang, K. D., Wang, Z., McMurray, M., Tkaczuk, A., Ogawa, Y., Hertzano, R., & Coate, T. M. (2019). Semaphorin-5B Controls Spiral Ganglion Neuron Branch Refinement during Development. The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(33), 6425–6438. https://doi.org/10.1523/JNEUROSCI.0113-19.2019

Weinreich, H. M., Khayat, S., Hertzano, R. P., Briggs, S. E., & Agrawal, Y. (2019). The Women in Neurotology (WIN)-A Cross-sectional Survey. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 40(5), 557–558. https://doi.org/10.1097/MAO.0000000000002268

So, E. C., Khaladj-Ghom, A., Ji, Y., Amin, J., Song, Y., Burch, E., Zhou, H., Sun, H., Chen, S., Bentzen, S., Hertzano, R., Zhang, X., & Strome, S. E. (2019). NK cell expression of Tim-3: First impressions matter. Immunobiology, 224(3), 362–370. https://doi.org/10.1016/j.imbio.2019.03.001

Hertzano, R., Tomlinson, J. A., & Mackowiak, P. A. (2019). Goya’s Lost Hearing: A Twenty-First Century Perspective on Its Cause, Effects and Possible Treatment. The American journal of the medical sciences, 357(4), 275–279. https://doi.org/10.1016/j.amjms.2018.12.009

Chessum, L., Matern, M. S., Kelly, M. C., Johnson, S. L., Ogawa, Y., Milon, B., McMurray, M., Driver, E. C., Parker, A., Song, Y., Codner, G., Esapa, C. T., Prescott, J., Trent, G., Wells, S., Dragich, A. K., Frolenkov, G. I., Kelley, M. W., Marcotti, W., Brown, S., … Hertzano, R. (2018). Helios is a key transcriptional regulator of outer hair cell maturation. Nature, 563(7733), 696–700. https://doi.org/10.1038/s41586-018-0728-4

Song, Y., Milon, B., Ott, S., Zhao, X., Sadzewicz, L., Shetty, A., Boger, E. T., Tallon, L. J., Morell, R. J., Mahurkar, A., & Hertzano, R. (2018). A comparative analysis of library prep approaches for sequencing low input translatome samples. BMC genomics, 19(1), 696. https://doi.org/10.1186/s12864-018-5066-2

Matern, M. S., Beirl, A., Ogawa, Y., Song, Y., Paladugu, N., Kindt, K. S., & Hertzano, R. (2018). Transcriptomic Profiling of Zebrafish Hair Cells Using RiboTag. Frontiers in cell and developmental biology, 6, 47. https://doi.org/10.3389/fcell.2018.00047

Eisenman, D. J., Raghavan, P., Hertzano, R., & Morales, R. (2018). Evaluation and treatment of pulsatile tinnitus associated with sigmoid sinus wall anomalies. The Laryngoscope, 128 Suppl 2, S1–S13. https://doi.org/10.1002/lary.27218

Milon, B., Mitra, S., Song, Y., Margulies, Z., Casserly, R., Drake, V., Mong, J. A., Depireux, D. A., & Hertzano, R. (2018). The impact of biological sex on the response to noise and otoprotective therapies against acoustic injury in mice. Biology of sex differences, 9(1), 12. https://doi.org/10.1186/s13293-018-0171-0

Joshi, S. S., Tandukar, B., Castaneda, M., Jiang, S., Diwakar, G., Hertzano, R. P., & Hornyak, T. J. (2018). Characterization of a new, inducible transgenic mouse model with GFP expression in melanocytes and their precursors. Gene expression patterns : GEP, 27, 76–84. https://doi.org/10.1016/j.gep.2017.10.003

Ortlip, T. E., Drake, V. E., Raghavan, P., Papadimitriou, J. C., Porter, N. C., Eisenman, D. J., & Hertzano, R. (2017). Inflammatory Pseudotumor of the Temporal Bone: A Case Series. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 38(7), 1024–1031. https://doi.org/10.1097/MAO.0000000000001465

Crowson, M. G., Hertzano, R., & Tucci, D. L. (2017). Emerging Therapies for Sensorineural Hearing Loss. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 38(6), 792–803. https://doi.org/10.1097/MAO.0000000000001427

Matern, M., Vijayakumar, S., Margulies, Z., Milon, B., Song, Y., Elkon, R., Zhang, X., Jones, S. M., & Hertzano, R. (2017). Gfi1Cre mice have early onset progressive hearing loss and induce recombination in numerous inner ear non-hair cells. Scientific reports, 7, 42079. https://doi.org/10.1038/srep42079

Hertzano, R., Teplitzky, T. B., & Eisenman, D. J. (2016). Clinical Evaluation of Tinnitus. Neuroimaging clinics of North America, 26(2), 197–205. https://doi.org/10.1016/j.nic.2015.12.004

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C. C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C. D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D. J., Eliyahu, E., Frolenkov, G. I., Strome, S. E., Durand, B., … Hertzano, R. (2015). RFX transcription factors are essential for hearing in mice. Nature communications, 6, 8549. https://doi.org/10.1038/ncomms9549

Harvey, R. S., Hertzano, R., Kelman, S. E., & Eisenman, D. J. (2014). Pulse-synchronous tinnitus and sigmoid sinus wall anomalies: descriptive epidemiology and the idiopathic intracranial hypertension patient population. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 35(1), 7–15. https://doi.org/10.1097/MAO.0b013e3182a4756c

Hertzano, R., & Elkon, R. (2012). High throughput gene expression analysis of the inner ear. Hearing research, 288(1-2), 77–88. https://doi.org/10.1016/j.heares.2012.01.002

Voskens, C. J., Sewell, D., Hertzano, R., DeSanto, J., Rollins, S., Lee, M., Taylor, R., Wolf, J., Suntharalingam, M., Gastman, B., Papadimitriou, J. C., Lu, C., Tan, M., Morales, R., Cullen, K., Celis, E., Mann, D., & Strome, S. E. (2012). Induction of MAGE-A3 and HPV-16 immunity by Trojan vaccines in patients with head and neck carcinoma. Head & neck, 34(12), 1734–1746. https://doi.org/10.1002/hed.22004

Hertzano, R., Elkon, R., Kurima, K., Morrisson, A., Chan, S. L., Sallin, M., Biedlingmaier, A., Darling, D. S., Griffith, A. J., Eisenman, D. J., & Strome, S. E. (2011). Cell type-specific transcriptome analysis reveals a major role for Zeb1 and miR-200b in mouse inner ear morphogenesis. PLoS genetics, 7(9), e1002309. https://doi.org/10.1371/journal.pgen.1002309

Kurima, K., Hertzano, R., Gavrilova, O., Monahan, K., Shpargel, K. B., Nadaraja, G., Kawashima, Y., Lee, K. Y., Ito, T., Higashi, Y., Eisenman, D. J., Strome, S. E., & Griffith, A. J. (2011). A noncoding point mutation of Zeb1 causes multiple developmental malformations and obesity in Twirler mice. PLoS genetics, 7(9), e1002307. https://doi.org/10.1371/journal.pgen.1002307

Hertzano, R., & Eisenman, D. J. (2011). Large, symptomatic tension pneumocele: 23 years after translabyrinthine resection of an acoustic neuroma. Otolaryngology–head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 144(3), 477–478. https://doi.org/10.1177/0194599810391602

Elkan-Miller, T., Ulitsky, I., Hertzano, R., Rudnicki, A., Dror, A. A., Lenz, D. R., Elkon, R., Irmler, M., Beckers, J., Shamir, R., & Avraham, K. B. (2011). Integration of transcriptomics, proteomics, and microRNA analyses reveals novel microRNA regulation of targets in the mammalian inner ear. PloS one, 6(4), e18195. https://doi.org/10.1371/journal.pone.0018195

Hertzano, R., & Eisenman, D. J. (2010). Stapes bar. Otolaryngology–head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 143(1), 163–164. https://doi.org/10.1016/j.otohns.2010.03.004

Hertzano, R., Puligilla, C., Chan, S. L., Timothy, C., Depireux, D. A., Ahmed, Z., Wolf, J., Eisenman, D. J., Friedman, T. B., Riazuddin, S., Kelley, M. W., & Strome, S. E. (2010). CD44 is a marker for the outer pillar cells in the early postnatal mouse inner ear. Journal of the Association for Research in Otolaryngology : JARO, 11(3), 407–418. https://doi.org/10.1007/s10162-010-0211-x

Zhang, X., Voskens, C. J., Sallin, M., Maniar, A., Montes, C. L., Zhang, Y., Lin, W., Li, G., Burch, E., Tan, M., Hertzano, R., Chapoval, A. I., Tamada, K., Gastman, B. R., Schulze, D. H., & Strome, S. E. (2010). CD137 promotes proliferation and survival of human B cells. Journal of immunology (Baltimore, Md. : 1950), 184(2), 787–795. https://doi.org/10.4049/jimmunol.0901619

Hertzano, R., Shalit, E., Rzadzinska, A. K., Dror, A. A., Song, L., Ron, U., Tan, J. T., Shitrit, A. S., Fuchs, H., Hasson, T., Ben-Tal, N., Sweeney, H. L., de Angelis, M. H., Steel, K. P., & Avraham, K. B. (2008). A Myo6 mutation destroys coordination between the myosin heads, revealing new functions of myosin VI in the stereocilia of mammalian inner ear hair cells. PLoS genetics, 4(10), e1000207. https://doi.org/10.1371/journal.pgen.1000207

Hertzano, R., Dror, A. A., Montcouquiol, M., Ahmed, Z. M., Ellsworth, B., Camper, S., Friedman, T. B., Kelley, M. W., & Avraham, K. B. (2007). Lhx3, a LIM domain transcription factor, is regulated by Pou4f3 in the auditory but not in the vestibular system. The European journal of neuroscience, 25(4), 999–1005. https://doi.org/10.1111/j.1460-9568.2007.05332.x

Fiolka, K., Hertzano, R., Vassen, L., Zeng, H., Hermesh, O., Avraham, K. B., Dührsen, U., & Möröy, T. (2006). Gfi1 and Gfi1b act equivalently in haematopoiesis, but have distinct, non-overlapping functions in inner ear development. EMBO reports, 7(3), 326–333. https://doi.org/10.1038/sj.embor.7400618

Clough, R. L., Sud, R., Davis-Silberman, N., Hertzano, R., Avraham, K. B., Holley, M., & Dawson, S. J. (2004). Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity. Biochemical and biophysical research communications, 324(1), 372–381. https://doi.org/10.1016/j.bbrc.2004.09.074

Rhodes, C. R., Hertzano, R., Fuchs, H., Bell, R. E., de Angelis, M. H., Steel, K. P., & Avraham, K. B. (2004). A Myo7a mutation cosegregates with stereocilia defects and low-frequency hearing impairment. Mammalian genome : official journal of the International Mammalian Genome Society, 15(9), 686–697. https://doi.org/10.1007/s00335-004-2344-x

Hertzano, R., Montcouquiol, M., Rashi-Elkeles, S., Elkon, R., Yücel, R., Frankel, W. N., Rechavi, G., Möröy, T., Friedman, T. B., Kelley, M. W., & Avraham, K. B. (2004). Transcription profiling of inner ears from Pou4f3(ddl/ddl) identifies Gfi1 as a target of the Pou4f3 deafness gene. Human molecular genetics, 13(18), 2143–2153. https://doi.org/10.1093/hmg/ddh218

Donaudy, F., Ferrara, A., Esposito, L., Hertzano, R., Ben-David, O., Bell, R. E., Melchionda, S., Zelante, L., Avraham, K. B., & Gasparini, P. (2003). Multiple mutations of MYO1A, a cochlear-expressed gene, in sensorineural hearing loss. American journal of human genetics, 72(6), 1571–1577. https://doi.org/10.1086/375654

Walsh, T., Walsh, V., Vreugde, S., Hertzano, R., Shahin, H., Haika, S., Lee, M. K., Kanaan, M., King, M. C., & Avraham, K. B. (2002). From flies’ eyes to our ears: mutations in a human class III myosin cause progressive nonsyndromic hearing loss DFNB30. Proceedings of the National Academy of Sciences of the United States of America, 99(11), 7518–7523. https://doi.org/10.1073/pnas.102091699